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HVCN1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HVCN1 Antibody (N-term) AP5042A
    Western blot analysis of HVCN1 Antibody (N-term)(Cat. #AP5042a) in Jurkat cell line lysates (35ug/lane).HVCN1 (arrow) was detected using the purified Pab.
  • FC - HVCN1 Antibody (N-term) AP5042A
    HVCN1 Antibody (N-term) (Cat. #AP5042a) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96D96
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31683 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 84329
Other Names Voltage-gated hydrogen channel 1, Hydrogen voltage-gated channel 1, HV1, Voltage sensor domain-only protein, HVCN1, VSOP
Target/Specificity This HVCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HVCN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHVCN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HVCN1
Synonyms VSOP
Function Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types
Tissue Location Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen
Research Areas
Citations (0)

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HVCN1 is a voltage-gated proton channel highly expressed in immune tissues. Channels like HVCN1 mediate the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing.


Musset, B., et al. J. Biol. Chem. 285(8):5117-5121(2010)
Lishko, P.V., et al. Cell 140(3):327-337(2010)
Sakata, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2313-2318(2010)

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Cat# AP5042A
(40 western blots)
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