|Calculated MW||30 24(R&D 25 and 30 kDa)|
|Antigen Region||84-110 aa|
|Other Names||Catechol O-methyltransferase, COMT|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.|
|Cellular Location||Isoform Soluble: Cytoplasm.|
|Tissue Location||Brain, liver, placenta, lymphocytes and erythrocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Lundstroem K.,et al.DNA Cell Biol. 10:181-189(1991).
Bertocci B.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991).
Tenhunen J.,et al.Eur. J. Biochem. 223:1049-1059(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.