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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   COMT Antibody   

COMT Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - COMT Antibody AP50677
    Western blot analysis of lysate from A431 cell line,using COMT Antibody(AP50677). AP50677 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P21964
Host Rabbit
Clonality Polyclonal
Calculated MW 30 24(R&D 25 and 30 kDa)
Antigen Region 84-110 aa
Additional Information
Gene ID 1312
Other Names Catechol O-methyltransferase, COMT
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name COMT
Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Cellular Location Isoform Soluble: Cytoplasm.
Tissue Location Brain, liver, placenta, lymphocytes and erythrocytes
Research Areas
Citations (0)

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Background

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

References

Lundstroem K.,et al.DNA Cell Biol. 10:181-189(1991).
Bertocci B.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991).
Tenhunen J.,et al.Eur. J. Biochem. 223:1049-1059(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).

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$ 295.00
Cat# AP50677
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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