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ZAR1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q86SH2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46 KDa |
| Antigen Region | 248-276 aa |
| Gene ID | 326340 |
|---|---|
| Other Names | Zygote arrest protein 1, Oocyte-specific maternal effect factor, ZAR1 |
| Dilution | WB~~ 1:1000 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | ZAR1 {ECO:0000303|PubMed:12539046, ECO:0000312|HGNC:HGNC:20436} |
|---|---|
| Function | mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation. |
| Cellular Location | Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q80SU3}. Cytoplasm {ECO:0000250|UniProtKB:Q80SU3}. Note=Specifically localizes to MARDO (mitochondria-associated ribonucleoprotein domain), a mitochondria- associated membraneless compartment that stores mRNAs in oocytes {ECO:0000250|UniProtKB:Q80SU3} |
| Tissue Location | Ovary and testis.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).
References
Wu X.,et al.Nat. Genet. 33:187-191(2003).
Wu X.,et al.Biol. Reprod. 69:861-867(2003).
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