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FOXD3 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9UJU5 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 48 KDa |
| Antigen Region | 230-258 aa |
| Gene ID | 27022 |
|---|---|
| Other Names | Forkhead box protein D3, HNF3/FH transcription factor genesis, FOXD3, HFH2 |
| Dilution | WB~~ 1:1000 IHC~~1:50~100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | FOXD3 |
|---|---|
| Synonyms | HFH2 |
| Function | Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor (PubMed:11891324). Also acts as a transcriptional activator (PubMed:11891324). Negatively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). Promotes development of neural crest cells from neural tube progenitors (PubMed:11891324). Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation (PubMed:11891324). Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (PubMed:11891324). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in chronic myeloid leukemia, Jurkat T- cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
References
Ramsey H.C.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Hromas R.,et al.Blood 81:2854-2859(1993).
Guo Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:3663-3667(2002).
Alkhateeb A.,et al.J. Invest. Dermatol. 125:388-391(2005).
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