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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MED23 Antibody   

MED23 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MED23 Antibody AP50842
    Western blot analysis of lysate from HeLa cell line,using MED23 Antibody, was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • IF - MED23 Antibody AP50842
    Immunofluorescence analysis of A549 cells, using MED23 antibody.
  • IHC - MED23 Antibody AP50842
    Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MED23 antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, IHC
Primary Accession Q9ULK4
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 156,101,54 KDa
Antigen Region 21-49 aa
Additional Information
Gene ID 9439
Other Names Mediator of RNA polymerase II transcription subunit 23, Activator-recruited cofactor 130 kDa component, ARC130, Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subunit 3, Mediator complex subunit 23, Protein sur-2 homolog, hSur-2, Transcriptional coactivator CRSP130, Vitamin D3 receptor-interacting protein complex 130 kDa component, DRIP130, MED23, ARC130, CRSP3, DRIP130, KIAA1216, SUR2
Dilution WB~~ 1:1000
IF~~1:100
IHC~~1:50~100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name MED23
Synonyms ARC130, CRSP3, DRIP130, KIAA1216, SUR2
Function Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.

References

Rachez C.,et al.Nature 398:824-828(1999).
Boyer T.G.,et al.Nature 399:276-279(1999).
Ryu S.,et al.Nature 397:446-450(1999).
Kivil A.,et al.Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 6:337-345(1999).

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$ 295.00
Cat# AP50842
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
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