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MED23 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IHC |
|---|---|
| Primary Accession | Q9ULK4 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 156,101,54 KDa |
| Antigen Region | 21-49 aa |
| Gene ID | 9439 |
|---|---|
| Other Names | Mediator of RNA polymerase II transcription subunit 23, Activator-recruited cofactor 130 kDa component, ARC130, Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subunit 3, Mediator complex subunit 23, Protein sur-2 homolog, hSur-2, Transcriptional coactivator CRSP130, Vitamin D3 receptor-interacting protein complex 130 kDa component, DRIP130, MED23, ARC130, CRSP3, DRIP130, KIAA1216, SUR2 |
| Dilution | IF~~1:100 WB~~ 1:1000 IHC~~1:50~100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | MED23 |
|---|---|
| Synonyms | ARC130, CRSP3, DRIP130, KIAA1216, SUR2 |
| Function | Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
References
Rachez C.,et al.Nature 398:824-828(1999).
Boyer T.G.,et al.Nature 399:276-279(1999).
Ryu S.,et al.Nature 397:446-450(1999).
Kivil A.,et al.Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 6:337-345(1999).
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