Rabbit Anti-DHCR7 antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q9UBM7 |
Reactivity | Human, Mouse, Rat, Chicken, Bovine, Horse, Dog |
Host | Rabbit |
Clonality | polyclonal |
Calculated MW | H=54; KDa |
Gene ID | 1717 |
---|---|
Other Names | 7-dehydrocholesterol reductase, 7-DHC reductase, Putative sterol reductase SR-2, Sterol Delta(7)-reductase, DHCR7, D7SR |
Dilution | WB~~1:1000 |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | DHCR7 |
---|---|
Synonyms | D7SR |
Function | 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7- dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien- 3beta-ol, two intermediates in that pathway. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Widely expressed. Most abundant in adrenal gland, liver, testis, and brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
References
Waterham H.R.,et al.Am. J. Hum. Genet. 63:329-338(1998).
Moebius F.F.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:1899-1902(1998).
Holmer L.,et al.Genomics 54:469-476(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wassif C.A.,et al.Am. J. Hum. Genet. 63:55-62(1998).
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