|Application ||WB, IHC-P, FC, E|
|Calculated MW||107457 Da|
|Antigen Region||236-264 aa|
|Other Names||Roundabout homolog 4, Magic roundabout, ROBO4|
|Target/Specificity||This Roundabout 4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-264 amino acids from the N-terminal region of human Roundabout 4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Roundabout 4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).|
|Tissue Location||Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Roundabout 4 is receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. This protein may mediate the inhibition of primary endothelial cell migration by Slit proteins.
Jones, C.A., et al. Nat. Cell Biol. 11(11):1325-1331(2009)
Sheldon, H., et al. FASEB J. 23(2):513-522(2009)
Huang, L., et al. Mol. Vis. 15, 1057-1069 (2009)
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