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Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | Q9H6S1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45 KDa |
| Other Names | 5-azacytidine-induced protein 2, NF-kappa-B-activating kinase-associated protein 1, Nak-associated protein 1, TILP, AZI2, NAP1, TBKBP2 |
|---|---|
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | AZI2 |
|---|---|
| Synonyms | NAP1, TBKBP2 |
| Function | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Widely expressed. Abundant expression seen in the pancreas and testis. EMBL; AY151386; AAO05967.1; -; mRNA EMBL; AF044917; AAF22368.1; -; Genomic_DNA EMBL; AF044918; AAF22369.1; -; Genomic_DNA EMBL; AK025592; BAB15182.1; -; mRNA EMBL; AK290637; BAF83326.1; -; mRNA EMBL; AC092503; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC098616; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471055; EAW64395.1; -; Genomic_DNA CCDS; CCDS2647.1; -. [Q9H6S1-1] CCDS; CCDS46782.1; -. [Q9H6S1-4] CCDS; CCDS46783.1; -. [Q9H6S1-5] RefSeq; NP_001127904.1; NM_001134432.1. [Q9H6S1-4] RefSeq; NP_001127905.1; NM_001134433.1. [Q9H6S1-5] RefSeq; NP_071906.1; NM_022461.4. [Q9H6S1-1] RefSeq; XP_005265449.1; XM_005265392.2. [Q9H6S1-1] UniGene; Hs.706676; - PDB; 5EP6; X-ray; 1.45 A; A/C=215-255 PDBsum; 5EP6; - ProteinModelPortal; Q9H6S1; - SMR; Q9H6S1; - BioGrid; 122142; 15 DIP; DIP-27605N; - IntAct; Q9H6S1; 12 MINT; MINT-1149019; - STRING; 9606.ENSP00000419371; - iPTMnet; Q9H6S1; - PhosphoSitePlus; Q9H6S1; - BioMuta; AZI2; - DMDM; 74718550; - EPD; Q9H6S1; - MaxQB; Q9H6S1; - PaxDb; Q9H6S1; - PeptideAtlas; Q9H6S1; - PRIDE; Q9H6S1; - DNASU; 64343; - Ensembl; ENST00000334100; ENSP00000335609; ENSG00000163512. [Q9H6S1-5] Ensembl; ENST00000420543; ENSP00000391696; ENSG00000163512. [Q9H6S1-4] Ensembl; ENST00000457172; ENSP00000389577; ENSG00000163512. [Q9H6S1-4] Ensembl; ENST00000479665; ENSP00000419371; ENSG00000163512. [Q9H6S1-1] GeneID; 64343; - KEGG; hsa:64343; - UCSC; uc003ceb.5; human. [Q9H6S1-1] CTD; 64343; - DisGeNET; 64343; - GeneCards; AZI2; - HGNC; HGNC:24002; AZI2 HPA; HPA035258; - HPA; HPA040816; - MIM; 609916; gene neXtProt; NX_Q9H6S1; - OpenTargets; ENSG00000163512; - PharmGKB; PA134950985; - eggNOG; ENOG410IG4Z; Eukaryota eggNOG; ENOG4111IT0; LUCA GeneTree; ENSGT00390000001279; - HOGENOM; HOG000013059; - HOVERGEN; HBG067551; - InParanoid; Q9H6S1; - KO; K12651; - OMA; KDSTKLH; - OrthoDB; EOG091G09UX; - PhylomeDB; Q9H6S1; - TreeFam; TF331289; - BioCyc; ZFISH:ENSG00000163512-MONOMER; - SignaLink; Q9H6S1; - ChiTaRS; AZI2; human GeneWiki; AZI2; - GenomeRNAi; 64343; - PRO; PR:Q9H6S1; - Proteomes; UP000005640; Chromosome 3 Bgee; ENSG00000163512; - CleanEx; HS_AZI2; - ExpressionAtlas; Q9H6S1; baseline and differential Genevisible; Q9H6S1; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl GO; GO:0044565; P:dendritic cell proliferation; IEA:Ensembl GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl GO; GO:0032607; P:interferon-alpha production; IEA:Ensembl GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl GO; GO:0042110; P:T cell activation; IEA:Ensembl GO; GO:0032640; P:tumor necrosis factor production; IEA:Ensembl InterPro; IPR024581; TBD Pfam; PF12845; TBD; 1 1: Evidence at protein level; 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome CHAIN 1 392 5-azacytidine-induced protein 2 /FTId=PRO_0000280602 REGION 1 197 Homodimerization. REGION 216 257 Interaction with TBK1 and IKBKE COILED 40 76 COILED 102 196 MOD_RES 318 318 Phosphoserine {ECO:0000250|UniProtKB:Q4KMA0} MOD_RES 353 353 Phosphoserine VAR_SEQ 216 243 SDNMQHAYWELKREMSNLHLVTQVQAEL -> RQSICSTAW SAVAQSWDSMNFEDCSLFA (in isoform 3) /FTId=VSP_047087 VAR_SEQ 216 232 SDNMQHAYWELKREMSN -> RVSVAQPGVQWRNHGIA (in isoform 4). /FTId=VSP_047088 VAR_SEQ 216 228 SDNMQHAYWELKR -> TQPGVQWRNHGIA (in isoform 2). /FTId=VSP_023817 VAR_SEQ 229 392 Missing (in isoform 2). /FTId=VSP_023818 VAR_SEQ 233 392 Missing (in isoform 4). /FTId=VSP_047089 VAR_SEQ 244 392 Missing (in isoform 3). /FTId=VSP_047090 HELIX 216 246 {ECO:0000244|PDB:5EP6} STRAND 247 249 {ECO:0000244|PDB:5EP6} SEQUENCE 392 AA; 44935 MW; EFDBDDA60C5CD624 CRC64; MDALVEDDIC ILNHEKAHKR DTVTPVSIYS GDESVASHFA LVTAYEDIKK RLKDSEKENS LLKKRIRFLE EKLIARFEEE TSSVGREQVN KAYHAYREVC IDRDNLKSKL DKMNKDNSES LKVLNEQLQS KEVELLQLRT EVETQQVMRN LNPPSSNWEV EKLSCDLKIH GLEQELELMR KECSDLKIEL QKAKQTDPYQ EDNLKSRDLQ KLSISSDNMQ HAYWELKREM SNLHLVTQVQ AELLRKLKTS TAIKKACAPV GCSEDLGRDS TKLHLMNFTA TYTRHPPLLP NGKALCHTTS SPLPGDVKVL SEKAILQSWT DNERSIPNDG TCFQEHSSYG RNSLEDNSWV FPSPPKSSET AFGETKTKTL PLPNLPPLHY LDQHNQNCLY KN |
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Background
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.
References
Fujita F.,et al.Mol. Cell. Biol. 23:7780-7793(2003).
Inohara N.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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$ 295.00
Cat# AP51007
Availability: 5-7 days
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