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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   CCKBR Antibody   

CCKBR Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CCKBR Antibody AP51051
    Anti-CCKBR Antibodyat 1:1000 dilution + H.brain tissue lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 48,56 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P32239
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 48 KDa
Additional Information
Gene ID 887
Other Names Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R, CCKBR, CCKRB
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CCKBR
Synonyms CCKRB
Function Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Research Areas
Citations (0)

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Background

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

References

Pisegna J.R.,et al.Biochem. Biophys. Res. Commun. 189:296-303(1992).
Lee Y.-M.,et al.J. Biol. Chem. 268:8164-8169(1993).
Ito M.,et al.J. Biol. Chem. 268:18300-18305(1993).
Song I.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:9085-9089(1993).
Herget T.,et al.Ann. N. Y. Acad. Sci. 713:283-297(1994).

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$ 295.00
Cat# AP51051
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
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