|Application ||WB, IHC-P, FC, E|
|Calculated MW||24750 Da|
|Antigen Region||88-116 aa|
|Other Names||Calcineurin B homologous protein 3, Tescalcin, TSC, TESC, CHP3|
|Target/Specificity||This TESC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the C-terminal region of human TESC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TESC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.|
|Cellular Location||Nucleus. Cytoplasm. Membrane. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Colocalizes with SLC9A1 at the plasma membrane|
|Tissue Location||Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta|
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Provided below are standard protocols that you may find useful for product applications.
Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation.
Bao, Y., et al. Gene Expr. Patterns 9(5):273-281(2009)
Zaun, H.C., et al. J. Biol. Chem. 283(18):12456-12467(2008)
Levay, K., et al. J. Clin. Invest. 117(9):2672-2683(2007)
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