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NEURL2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9BR09 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32 KDa |
| Antigen Region | 81 - 140 aa |
| Gene ID | 140825 |
|---|---|
| Other Names | Neuralized-like protein 2, NEURL2, C20orf163 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human NEURL2 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | NEURL2 |
|---|---|
| Synonyms | C20orf163 |
| Function | Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed specifically in skeletal and cardiac muscles. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Frigimelica E.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Nastasi T.,et al.Dev. Cell 6:269-282(2004).
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