|Calculated MW||56 KDa|
|Other Names||Protein RCC2, RCC1-like protein TD-60, Telophase disk protein of 60 kDa, RCC2, KIAA1470, TD60|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.|
|Cellular Location||Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex|
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Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.
Mollinari C.,et al.Dev. Cell 5:295-307(2003).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Andreassen P.R.,et al.J. Cell Sci. 99:523-534(1991).
Martineau S.N.,et al.J. Cell Biol. 131:191-205(1995).
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