|Calculated MW||26 KDa|
|Antigen Region||91 - 150 aa|
|Other Names||Ras-related protein R-Ras2, Ras-like protein TC21, Teratocarcinoma oncogene, RRAS2, TC21|
|Target/Specificity||KLH conjugated synthetic peptide derived from human RRAS2|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS)|
|Tissue Location||Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.|
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It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.
Drivas G.T.,et al.Mol. Cell. Biol. 10:1793-1798(1990).
Chan A.M.-L.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:7558-7562(1994).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
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