|Application ||WB, IHC-P, FC, E|
|Calculated MW||49448 Da|
|Antigen Region||142-170 aa|
|Other Names||UMP-CMP kinase 2, mitochondrial, Nucleoside-diphosphate kinase, CMPK2|
|Target/Specificity||This CMPK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-170 amino acids from the Central region of human CMPK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CMPK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.|
|Tissue Location||Among all investigated tumors, leukemia cells show the most abundant expression.|
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Provided below are standard protocols that you may find useful for product applications.
Mitochondrial UMP-CMP kinase (EC 18.104.22.168) is a component of the salvage pathway for nucleotide synthesis. Other enzymes of the salvage pathway include thymidine kinase-2 (TK2; MIM 188250), deoxynucleotidase-2 (NT5M; MIM 605292), deoxyguanosine kinase (DGUOK; MIM 601465), adenylate kinase-2 (AK2; MIM 103020), adenylate kinase-3 (AK3; MIM 609290), adenylate kinase-3-like-1 (AK3L1; MIM 103030), and nucleoside diphosphate kinase.
Xu, Y., et al. J. Biol. Chem. 283(3):1563-1571(2008)
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