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Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF |
|---|---|
| Primary Accession | P19022 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 99809 Da |
| Gene ID | 1000 |
|---|---|
| Other Names | CDHN; NCAD; CD325; CDw325; Cadherin-2; Neural cadherin; N-cadherin; CDH2 |
| Dilution | WB~~1:100~1:500 IHC-P~~1:100~1:500 IF~~1:100~1:200 |
| Format | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CDH2 |
|---|---|
| Synonyms | CDHN, NCAD |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P15116}; Single-pass type I membrane protein. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes {ECO:0000250|UniProtKB:P15116} |
Provided below are standard protocols that you may find useful for product applications.
Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).
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