|Application ||IHC-P, WB, E|
|Other Accession||D4ABB4, Q91W61, E1BNS0|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||32998 Da|
|Antigen Region||252-280 aa|
|Other Names||F-box/LRR-repeat protein 15, F-box only protein 37, FBXL15, FBXO37|
|Target/Specificity||This FBXL15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-280 amino acids from the C-terminal region of human FBXL15.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXL15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.|
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Provided below are standard protocols that you may find useful for product applications.
FBXL15 is probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Deloukas, P., et al. Nature 429(6990):375-381(2004)
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