|Application ||WB, FC, E|
|Other Accession||Q9WVA9, Q9WVA8, Q9TUX7|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||12440 Da|
|Antigen Region||86-113 aa|
|Other Names||Pro-FMRFamide-related neuropeptide FF, FMRFamide-related peptides, Neuropeptide SF, NPSF, Neuropeptide FF, NPFF, Neuropeptide AF, NPAF, NPFF|
|Target/Specificity||This NPFF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-113 amino acids from the C-terminal region of human NPFF.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NPFF Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.|
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Provided below are standard protocols that you may find useful for product applications.
FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function.
Yang, H.Y., et al. Neuropeptides 42(1):1-18(2008)
Roumy, M., et al. J. Biol. Chem. 282(11):8332-8342(2007)
Anko, M.L., et al. J. Neurochem. 96(2):573-584(2006)
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