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Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, FC |
|---|---|
| Primary Accession | Q99717 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 60 KDa |
| Gene ID | 4090 |
|---|---|
| Other Names | DKFZp781C1895;DKFZp781O1323;Dwfc;hSmad 5;hSmad5;JV5 1;JV5-1;MAD homolog 5;MAD mothers against decapentaplegic homolog 5;MAD, mothers against decapentaplegic homolog 5;MADH 5;MADH5;Mothers against decapentaplegic homolog 5;Mothers against DPP homolog 5;MusMLP; SMA and MAD related protein 5;SMAD 5;SMAD family member 5;SMAD mothers against DPP homolog 5;Smad5;Smad5;SMAD5_HUMAN. |
| Dilution | WB~~1:1000 ICC~~1:75 FC~~1:100 |
| Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SMAD5 |
|---|---|
| Synonyms | MADH5 |
| Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). |
| Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
References
Riggins G.J.,et al.Nat. Genet. 13:347-349(1996).
Hejlik D.P.,et al.Cancer Res. 57:3779-3783(1997).
Zavadil J.,et al.Leukemia 11:1187-1192(1997).
Gemma A.,et al.Oncogene 16:951-956(1998).
Nishimura R.,et al.J. Biol. Chem. 273:1872-1879(1998).
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