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SRD5A3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - SRD5A3 Antibody (C-term) AP5276b
    SRD5A3 Antibody (C-term) (Cat. #AP5276b) western blot analysis in 293,LNCaP,PC-3,NCI-H292 cell line lysates (35ug/lane).This demonstrates the SRD5A3 antibody detected the SRD5A3 protein (arrow).
  • IHC-P - SRD5A3 Antibody (C-term) AP5276b
    SRD5A3 Antibody (C-term) (Cat. #AP5276b) IHC analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SRD5A3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - SRD5A3 Antibody (C-term) AP5276b
    SRD5A3 Antibody (C-term) (Cat. #AP5276b) flow cytometric analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H8P0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 36521 Da
Antigen Region 283-311 aa
Additional Information
Gene ID 79644
Other Names Polyprenol reductase, 3-oxo-5-alpha-steroid 4-dehydrogenase 3, Steroid 5-alpha-reductase 2-like, Steroid 5-alpha-reductase 3, S5AR 3, SR type 3, SRD5A3, SRD5A2L
Target/Specificity This SRD5A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human SRD5A3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSRD5A3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SRD5A3
Synonyms SRD5A2L
Function Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs.
Research Areas
Citations (0)

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SRD5A3 converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT).


Uemura, M., et al. Cancer Sci. 99(1):81-86(2008)

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$ 295.00
$ 99.00
Cat# AP5276b
(40 western blots)
Availability: In Stock
Bulk Size
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