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DR5 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - DR5 Antibody AP52786
    Western blot detection of DR5 in Mouse kindey,Mouse brain,HCT116 and Hela cell lysates using DR5 mouse mAb (1:500-1:2000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.
  • ICC - DR5 Antibody AP52786
    Immunocytochemistry of HeLa cells fixed by Paraformaldehyde and using DR5 mouse mAb diluted 1:100.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, ICC
Primary Accession O14763
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 48 KDa
Additional Information
Gene ID 8795
Other Names Fas like protein;Apoptosis inducing protein TRICK2A/2B;Apoptosis inducing receptor TRAIL R2;CD 262;CD262;CD262 antigen;Cytotoxic TRAIL receptor 2;Death domain containing receptor for TRAIL/Apo 2L;Death domain containing receptor for TRAIL/Apo2L;Death receptor 5;DR 5;DR5;Fas like protein precursor;KILLER;KILLER/DR5;OTTHUMP00000123492; OTTHUMP00000123493;p53 regulated DNA damage inducible cell death receptor (killer);p53 regulated DNA damage inducible cell death receptor(killer);TNF related apoptosis inducing ligand receptor 2;TNF related apoptosis inducing ligand receptor 2;TNF-related apoptosis-inducing ligand receptor 2;TNFRSF10B;TR10B_HUMAN;TRAIL R2;TRAIL receptor 2;TRAIL-R2;TRAILR2;TRANCER;TRICK2;TRICK2A;TRICK2B;TRICKB;Tumor necrosis factor receptor like protein ZTNFR9;Tumor necrosis factor receptor like protein ZTNFR9;Tumor necrosis factor receptor superfamily member 10b;Tumor necrosis factor receptor superfamily, member 10b;ZTNFR9.
Dilution WB~~1:500-1:2000
ICC~~1:100
Format Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name TNFRSF10B
Synonyms DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain
Research Areas
Citations (0)

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Background

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.

References

Screaton G.R.,et al.Curr. Biol. 7:693-696(1997).
Walczak H.,et al.EMBO J. 16:5386-5397(1997).
Schneider P.,et al.FEBS Lett. 416:329-334(1997).
Chaudhary P.M.,et al.Immunity 7:821-830(1997).
MacFarlane M.,et al.J. Biol. Chem. 272:25417-25420(1997).

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$ 295.00
Cat# AP52786
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
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