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4E-BP2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

  • WB - 4E-BP2 Antibody AP52865
    Western blot detection of 4E-BP2 in CHO-K1 cell lysate(A)and CHO-K1 transfected by EGFP-4E-BP2 (B)cell lysate using 4E-BP2 mouse mAb (1:1000 diluted).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13542
Reactivity Transfected
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 15-20 KDa
Additional Information
Gene ID 1979
Other Names 4E-BP2 ; 4EBP2 ; 4EBP2_HUMAN ; eIF4E binding protein 2 ; eIF4E-binding protein 2 ; Eif4ebp2 ; Eukaryotic translation initiation factor 4E binding protein 1 ; Eukaryotic translation initiation factor 4E-binding protein 2 ; PHASII ; phosphorylated, heat and acid stable regulated by insulin protein II.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name EIF4EBP2 (HGNC:3289)
Function Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).
Research Areas
Citations (0)

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Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.


Pause A.,et al.Nature 371:762-767(1994).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).

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$ 295.00
Cat# AP52865
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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