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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   YLAT2 Antibody (C-term)   

YLAT2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - YLAT2 Antibody  (C-term) AP5300b
    Western blot analysis of YLAT2 Antibody (C-term) (Cat. #AP5300b) in HepG2 cell line lysates (35ug/lane).YLAT2 (arrow) was detected using the purified Pab.
  • FC - YLAT2 Antibody  (C-term) AP5300b
    YLAT2 Antibody (C-term) (Cat. #AP5300b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q92536
Other Accession NP_003974.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 56828 Da
Antigen Region 487-515 aa
Additional Information
Gene ID 9057
Other Names Y+L amino acid transporter 2, Cationic amino acid transporter, y+ system, Solute carrier family 7 member 6, y(+)L-type amino acid transporter 2, Y+LAT2, y+LAT-2, SLC7A6 (HGNC:11064)
Target/Specificity This YLAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-515 amino acids from the C-terminal region of human YLAT2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsYLAT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC7A6 (HGNC:11064)
Function Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
Cellular Location Basolateral cell membrane; Multi- pass membrane protein
Tissue Location Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.
Research Areas
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Background

This protein involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. It requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. It also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. It plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It involved in the transport of L-arginine in monocytes and reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.

References

Sekine, Y., et al. J. Am. Soc. Nephrol. 20(7):1586-1596(2009)
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Xu, D., et al. Mol. Cell Proteomics 4(8):1061-1071(2005)

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Cat# AP5300b
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(40 western blots)
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