|Calculated MW||15 KDa|
|Antigen Region||85-134 aa|
|Other Names||39S ribosomal protein L41, mitochondrial, L41mt, MRP-L41, 39S ribosomal protein L27 homolog, Bcl-2-interacting mitochondrial ribosomal protein L41, Cell proliferation-inducing gene 3 protein, MRP-L27 homolog, MRPL41, BMRP, MRPL27, RPML27|
|Format||Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Synonyms||BMRP, MRPL27, RPML27|
|Function||Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).|
|Tissue Location||Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level)|
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Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Kim J.W.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
Kenmochi N.,et al.Genomics 77:65-70(2001).
Koc E.C.,et al.J. Biol. Chem. 276:43958-43969(2001).
Chintharlapalli S.R.,et al.J. Cell. Biochem. 94:611-626(2005).
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