|Immunogen||Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.|
|Calculated MW||103829 Da|
|Other Names||CD283 ; CD283 antigen ; IIAE2 ; TLR 3 ; Tlr3 ; TLR3_HUMAN ; Toll Like Receptor 3 ; Toll-like receptor 3.|
|Format||Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane|
|Tissue Location||Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.|
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Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-st
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