|Application ||WB, IHC-P, E|
|Calculated MW||61922 Da|
|Antigen Region||492-519 aa|
|Other Names||Multidrug and toxin extrusion protein 1, MATE-1, hMATE-1, Solute carrier family 47 member 1, SLC47A1, MATE1|
|Target/Specificity||This SLC47A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-519 amino acids from the C-terminal region of human SLC47A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC47A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Predominantly localized at the plasma membrane but also found in intracellular organelles|
|Tissue Location||Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).|
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Provided below are standard protocols that you may find useful for product applications.
SLC47A1 is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function.
Toyama, K., et al. Pharmacogenet. Genomics 20(2):135-138(2010)
Becker, M.L., et al. Pharmacogenet. Genomics 20(1):38-44(2010)
Ha Choi, J., et al. Pharmacogenet. Genomics 19(10):770-780(2009)
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