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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   SIKE Antibody (C-term)   

SIKE Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SIKE Antibody (C-term) AP5375b
    SIKE Antibody (C-term)(Cat. #AP5375b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SIKE antibody detected the SIKE protein (arrow).
  • IHC-P - SIKE Antibody (C-term) AP5375b
    SIKE Antibody (C-term) (Cat. #AP5375b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SIKE Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BRV8
Other Accession Q5FWT9, Q0VCF3, NP_001095866.1, NP_079349.2
Reactivity Human
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23721 Da
Antigen Region 154-182 aa
Additional Information
Gene ID 80143
Other Names Suppressor of IKBKE 1, Suppressor of IKK-epsilon, SIKE1, SIKE
Target/Specificity This SIKE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-182 amino acids from the C-terminal region of human SIKE.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIKE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIKE1
Synonyms SIKE
Function Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
Cellular Location Cytoplasm.
Tissue Location Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
Research Areas
Citations (0)

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SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).


Goudreault, M., et al. Mol. Cell Proteomics 8(1):157-171(2009)
Huang, J., et al. EMBO J. 24(23):4018-4028(2005)

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$ 295.00
$ 99.00
Cat# AP5375b
(40 western blots)
Availability: In Stock
Bulk Size
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