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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AXIN2 Antibody (C-term)   

AXIN2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AXIN2 Antibody (C-term) AP5416b
    AXIN2 Antibody (C-term)(Cat. #AP5416b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the AXIN2 antibody detected the AXIN2 protein (arrow).
  • IHC-P - AXIN2 Antibody (C-term) AP5416b
    AXIN2 Antibody (C-term) (Cat. #AP5416b) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AXIN2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - AXIN2 Antibody (C-term) AP5416b
    AXIN2 Antibody (C-term) (Cat. #AP5416b) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2T1
Other Accession O70240, O88566, NP_004646.3
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 93558 Da
Antigen Region 816-843 aa
Additional Information
Gene ID 8313
Other Names Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2
Target/Specificity This AXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAXIN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AXIN2
Function Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity).
Cellular Location Cytoplasm.
Tissue Location Expressed in brain and lymphoblast.
Research Areas
Citations (0)

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The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.


Inkster, B., et al. Neuroimage (2010) In press :
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Olschwang, S., et al. J Oncol 2009, 306786 (2009) :
Dong, X., et al. Cytogenet. Cell Genet. 93 (1-2), 26-28 (2001) :
Liu, W., et al. Nat. Genet. 26(2):146-147(2000)
von Kries, J.P., et al. Nat. Struct. Biol. 7(9):800-807(2000)
Kikuchi, A. Cytokine Growth Factor Rev. 10 (3-4), 255-265 (1999) :
Mai, M., et al. Genomics 55(3):341-344(1999)

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$ 295.00
$ 99.00
Cat# AP5416b
(40 western blots)
Availability: In Stock
Bulk Size
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