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GKAP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q5VSY0 |
| Other Accession | Q5XIG5, Q9JMB0, Q32LE2, NP_001129425.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42078 Da |
| Antigen Region | 331-359 aa |
| Gene ID | 80318 |
|---|---|
| Other Names | G kinase-anchoring protein 1, cGMP-dependent protein kinase-anchoring protein of 42 kDa, GKAP1, GKAP42 |
| Target/Specificity | This GKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-359 amino acids from the C-terminal region of human GKAP1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GKAP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GKAP1 |
|---|---|
| Synonyms | GKAP42 |
| Function | Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. |
| Cellular Location | Golgi apparatus {ECO:0000250|UniProtKB:Q9JMB0}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GKAP1 is a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene.
References
Lim, J., et al. Cell 125(4):801-814(2006)
Sweetser, D.A., et al. Genes Chromosomes Cancer 44(3):279-291(2005)
Yuasa, K., et al. J. Biol. Chem. 275(7):4897-4905(2000)
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