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INMT Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - INMT Antibody (Center) AP5476c
    INMT Antibody (Center) (Cat.#AP5476c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the INMT antibody detected INMT protein (arrow).
  • IHC-P - INMT Antibody (Center) AP5476c
    INMT Antibody (Center) (Cat. #AP5476c) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the INMT Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95050
Other Accession NP_006765.4
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28891 Da
Antigen Region 101-128 aa
Additional Information
Gene ID 11185
Other Names Indolethylamine N-methyltransferase, Indolamine N-methyltransferase, Aromatic alkylamine N-methyltransferase, Amine N-methyltransferase, Arylamine N-methyltransferase, Thioether S-methyltransferase, TEMT, INMT
Target/Specificity This INMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-128 amino acids from the Central region of human INMT.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsINMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.
Cellular Location Cytoplasm.
Tissue Location Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain.
Research Areas
Citations (0)

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N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. [provided by RefSeq].


Kim, Y.H., et al. Exp. Mol. Med. 33(1):23-28(2001)
Thompson, M.A., et al. Genomics 61(3):285-297(1999)
Strahilevitz, M., et al. Biol. Psychiatry 12(2):171-180(1977)

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Cat# AP5476c
(40 western blots)
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