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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CTTB2 Antibody (N-term)   

CTTB2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CTTB2 Antibody (N-term) AP5490a
    CTTB2 Antibody (N-term) (Cat.#AP5490a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CTTB2 antibody detected the CTTB2 protein (arrow).
  • IHC-P - CTTB2 Antibody (N-term) AP5490a
    CTTB2 Antibody (N-term) (Cat. #AP5490a) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CTTB2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8WZ74
Other Accession Q2IBD4, NP_219499.1, Q2QLA2
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 72-100 aa
Additional Information
Other Names Cortactin-binding protein 2, CortBP2, CTTNBP2, C7orf8, CORTBP2, KIAA1758
Target/Specificity This CTTB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-100 amino acids from the N-terminal region of human CTTB2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTTB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTTNBP2
Synonyms C7orf8, CORTBP2, KIAA1758
Function Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
Cellular Location Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation
Tissue Location Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta. EMBL; AF377960; AAL32176.1; -; mRNA EMBL; DQ354388; ABC79049.1; -; Genomic_DNA EMBL; DQ354389; ABC79051.1; -; Genomic_DNA EMBL; DQ354390; ABC79053.1; -; Genomic_DNA EMBL; DQ354391; ABC79055.1; -; Genomic_DNA EMBL; DQ356257; ABC87052.1; -; Genomic_DNA EMBL; DQ356259; ABC87056.1; -; Genomic_DNA EMBL; DQ356260; ABC87058.1; -; Genomic_DNA EMBL; DQ356261; ABC87060.1; -; Genomic_DNA EMBL; DQ356262; ABC87062.1; -; Genomic_DNA EMBL; DQ356264; ABC87066.1; -; Genomic_DNA EMBL; AC004240; AAC04501.2; -; Genomic_DNA EMBL; BC106000; AAI06001.1; -; mRNA EMBL; AB051545; BAB21849.1; -; mRNA CCDS; CCDS5774.1; - RefSeq; NP_219499.1; NM_033427.2 UniGene; Hs.592285; - ProteinModelPortal; Q8WZ74; - SMR; Q8WZ74; - BioGrid; 123842; 26 IntAct; Q8WZ74; 32 STRING; 9606.ENSP00000160373; - iPTMnet; Q8WZ74; - PhosphoSitePlus; Q8WZ74; - BioMuta; CTTNBP2; - DMDM; 74751641; - EPD; Q8WZ74; - MaxQB; Q8WZ74; - PaxDb; Q8WZ74; - PeptideAtlas; Q8WZ74; - PRIDE; Q8WZ74; - ProteomicsDB; 75231; - Ensembl; ENST00000160373; ENSP00000160373; ENSG00000077063 GeneID; 83992; - KEGG; hsa:83992; - UCSC; uc003vjf.4; human CTD; 83992; - DisGeNET; 83992; - EuPathDB; HostDB:ENSG00000077063.10; - GeneCards; CTTNBP2; - HGNC; HGNC:15679; CTTNBP2 HPA; CAB009151; - HPA; HPA044654; - MIM; 609772; gene neXtProt; NX_Q8WZ74; - OpenTargets; ENSG00000077063; - PharmGKB; PA26774; - eggNOG; ENOG410IGN3; Eukaryota eggNOG; COG0666; LUCA GeneTree; ENSGT00910000144056; - HOGENOM; HOG000112055; - HOVERGEN; HBG073485; - InParanoid; Q8WZ74; - OMA; KHRQMAA; - OrthoDB; EOG091G0CSA; - PhylomeDB; Q8WZ74; - TreeFam; TF325130; - ChiTaRS; CTTNBP2; human GeneWiki; CTTNBP2; - GenomeRNAi; 83992; - PRO; PR:Q8WZ74; - Proteomes; UP000005640; Chromosome 7 Bgee; ENSG00000077063; - CleanEx; HS_CTTNBP2; - ExpressionAtlas; Q8WZ74; baseline and differential Genevisible; Q8WZ74; HS GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl GO; GO:0007420; P:brain development; IEA:Ensembl CDD; cd00204; ANK; 1 Gene3D; 1.25.40.20; -; 2 InterPro; IPR002110; Ankyrin_rpt InterPro; IPR020683; Ankyrin_rpt-contain_dom InterPro; IPR036770; Ankyrin_rpt-contain_sf InterPro; IPR019131; Cortactin-binding_p2_N Pfam; PF12796; Ank_2; 2 Pfam; PF09727; CortBP2; 1 SMART; SM00248; ANK; 6 SUPFAM; SSF48403; SSF48403; 2 PROSITE; PS50297; ANK_REP_REGION; 1 PROSITE; PS50088; ANK_REPEAT; 4 1: Evidence at protein level; ANK repeat; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Methylation; Phosphoprotein; Polymorphism; Reference proteome; Repeat CHAIN 1 1663 Cortactin-binding protein 2 /FTId=PRO_0000227002 REPEAT 709 739 ANK 1 REPEAT 743 772 ANK 2 REPEAT 776 805 ANK 3 REPEAT 809 838 ANK 4 REPEAT 842 871 ANK 5 REPEAT 912 942 ANK 6 COILED 119 276 COMPBIAS 371 561 Pro-rich MOD_RES 498 498 Asymmetric dimethylarginine {ECO:0000250|UniProtKB:B9EJA2} MOD_RES 1524 1524 Phosphoserine VARIANT 1148 1148 Q -> K (in dbSNP:rs10274022) /FTId=VAR_048294 VARIANT 1213 1213 L -> V (in dbSNP:rs62617115) /FTId=VAR_025535 SEQUENCE 1663 AA; 181051 MW; 367B933A177D6E3B CRC64; MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK KPVCTNPLSI LEAVMAHCKK MQERMSAQLA AAESRQKKLE MEKLQLQALE QEHKKLAARL EEERGKNKQV VLMLVKECKQ LSGKVIEEAQ KLEDVMAKLE EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ LRAKLNREEA HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT MARPGIDRQA SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP LPSNAAPPTA QTPGIAPQNS QAPPMHSLHS PCANTSLHPG LNPRIQAARF RFQGNANDPD QNGNTTQSPP SRDVSPTSRD NLVAKQLARN TVTQALSRFT SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG NPPPIPPKKP GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA CSDSSLVIPT TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR PTLLQQAAAQ GNVTLLSMLL NEEGLDINYS CEDGHSALYS AAKNGHTDCV RLLLSAEAQV NAADKNGFTP LCAAAAQGHF ECVELLISYD ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT TDGWTPVHAA VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV HDVATDDCKH LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI RKQTSWDDFS KAVSQALTNH FQAISSDGWW SLEDVTCNNT TDSNIGLSAR SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK AEHITVLLSG PQEGCLSSVT YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL ALCLKHRQMA AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA KACLQGSDLL VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP CDPVCKIVDW ALSVWRQLNS CLARLGTPEA LLGPKYFLSC PVVPGHAQVT VKWMSKLWNG VIAPRVQEAI LSRASVKRQP GFGQTTAKRH PSQGQQAVVK AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS SYNTCNKKKG ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA DSRDDLRMFD SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS KTELGVSRVK SFLPVPRSKV TQCSQNTKRS SSSSNTRQIE INNNSKEVNW NLHKNEHLEK PNK
Research Areas
Citations (0)

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Background

CTTB2 is a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq].

References

Zink, D., et al. J. Cell Biol. 166(6):815-825(2004)
Cheung, J., et al. Genomics 78 (1-2), 7-11 (2001)
Ohoka, Y., et al. Genes Cells 3(9):603-612(1998)

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Cat# AP5490a
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