|Application ||WB, IHC-P, E|
|Other Accession||Q2IBD4, NP_219499.1, Q2QLA2|
|Calculated MW||181051 Da|
|Antigen Region||72-100 aa|
|Other Names||Cortactin-binding protein 2, CortBP2, CTTNBP2, C7orf8, CORTBP2, KIAA1758|
|Target/Specificity||This CTTB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-100 amino acids from the N-terminal region of human CTTB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTTB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C7orf8, CORTBP2, KIAA1758|
|Function||Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.|
|Cellular Location||Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation|
|Tissue Location||Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
CTTB2 is a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq].
Zink, D., et al. J. Cell Biol. 166(6):815-825(2004)
Cheung, J., et al. Genomics 78 (1-2), 7-11 (2001)
Ohoka, Y., et al. Genes Cells 3(9):603-612(1998)
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