|Application ||WB, IHC-P, FC, E|
|Calculated MW||57313 Da|
|Antigen Region||30-59 aa|
|Other Names||Protein-cysteine N-palmitoyltransferase HHAT, 231-, Hedgehog acyltransferase, Melanoma antigen recognized by T-cells 2, MART-2, Skinny hedgehog protein 1, HHAT, MART2, SKI1|
|Target/Specificity||This HHAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human HHAT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HHAT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Ubiquitously expressed in normal tissues and cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).
Chamoun, Z., et al. Science 293(5537):2080-2084(2001)
Kawakami, Y., et al. J. Immunol. 166(4):2871-2877(2001)
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