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TM165 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q9HC07 |
| Other Accession | NP_060945.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34906 Da |
| Antigen Region | 17-45 aa |
| Gene ID | 55858 |
|---|---|
| Other Names | Transmembrane protein 165, Transmembrane protein PT27, Transmembrane protein TPARL, TMEM165, TPARL |
| Target/Specificity | This TM165 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human TM165. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TM165 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM165 {ECO:0000303|PubMed:32047108, ECO:0000312|HGNC:HGNC:30760} |
|---|---|
| Function | Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (PubMed:32047108, PubMed:23569283, PubMed:22683087, PubMed:27008884) (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated. |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:P52875}; Multi-pass membrane protein |
| Tissue Location | Ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of TM165 remains unknown.
References
Terracciano, A., et al. Mol. Psychiatry (2008)
Hu, R.M., et al. Proc. Natl. Acad. Sci. U.S.A. 97(17):9543-9548(2000)
Akagi, J., et al. Biochem. Biophys. Res. Commun. 157(2):548-557(1988)
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