|Application ||WB, E|
|Calculated MW||51293 Da|
|Antigen Region||105-132 aa|
|Other Names||Mitochondrial dynamics protein MID51, Mitochondrial dynamics protein of 51 kDa, Mitochondrial elongation factor 1, Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like, SMCR7-like protein, MIEF1, MID51, SMCR7L|
|Target/Specificity||This SMCR7L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-132 amino acids from the N-terminal region of human SMCR7L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMCR7L Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.|
|Cellular Location||Mitochondrion outer membrane; Single-pass membrane protein|
|Tissue Location||Expression is relatively high in heart, skeletal muscle, pancreas and kidney|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SMCR7L belongs to the SMCR7 family. The specific function of this protein remains unknown.
Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Dunham, I., et al. Nature 402(6761):489-495(1999)
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