|Application ||WB, IHC-P, E|
|Calculated MW||41899 Da|
|Antigen Region||87-116 aa|
|Other Names||Muscle-related coiled-coil protein, Muscle-restricted coiled-coil protein, MURC|
|Target/Specificity||This MURC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human MURC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MURC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.|
|Cellular Location||Cytoplasm, myofibril, sarcomere. Cytoplasm. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
MURC induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.
Tagawa, M., et al. Am. J. Physiol., Cell Physiol. 295 (2), C490-C498 (2008) :
Ogata, T., et al. Mol. Cell. Biol. 28(10):3424-3436(2008)
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