|Application ||WB, IHC-P, E|
|Calculated MW||41899 Da|
|Antigen Region||87-116 aa|
|Other Names||Muscle-related coiled-coil protein, Muscle-restricted coiled-coil protein, MURC|
|Target/Specificity||This MURC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human MURC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MURC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.|
|Cellular Location||Cytoplasm, myofibril, sarcomere. Cytoplasm. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (By similarity).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
MURC induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.
Tagawa, M., et al. Am. J. Physiol., Cell Physiol. 295 (2), C490-C498 (2008) :
Ogata, T., et al. Mol. Cell. Biol. 28(10):3424-3436(2008)
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