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IKZF3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IKZF3 Antibody (Center) AP5656C
    IKZF3 Antibody (Center) (Cat. #AP5656c) western blot analysis in mouse liver tissue lysates (15ug/lane).This demonstrates the IKZF3 antibody detected IKZF3 protein (arrow).
  • WB - IKZF3 Antibody (Center) AP5656C
    Western blot analysis of extracts from MM cells, treated with DMSO or lenalidomide, using rabbit polyclonal IKZF3 Antibody (Center) (Cat. #AP5656c).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UKT9
Other Accession A2VDW9, NP_036613.2
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58023 Da
Antigen Region 76-103 aa
Additional Information
Gene ID 22806
Other Names Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3
Target/Specificity This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIKZF3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IKZF3
Synonyms ZNFN1A3
Function Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner.
Cellular Location Nucleus. Cytoplasm.
Tissue Location Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus
Citations (0)

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This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.


Billot, K., et al. Leuk. Res. 34(3):289-293(2010)
Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)

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Cat# AP5656C
(40 western blots)
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