|Application ||WB, E|
|Other Accession||A2VDW9, NP_036613.2|
|Calculated MW||58023 Da|
|Antigen Region||76-103 aa|
|Other Names||Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3|
|Target/Specificity||This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IKZF3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
Billot, K., et al. Leuk. Res. 34(3):289-293(2010)
Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
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