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TANK Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| FC, WB, IHC-P, E |
|---|---|
| Primary Accession | Q92844 |
| Other Accession | NP_004171.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47816 Da |
| Antigen Region | 88-114 aa |
| Gene ID | 10010 |
|---|---|
| Other Names | TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAF, TANK, ITRAF, TRAF2 |
| Target/Specificity | This TANK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-114 amino acids from the Central region of human TANK. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TANK Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TANK |
|---|---|
| Synonyms | ITRAF, TRAF2 |
| Function | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1- mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2- mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Ubiquitous. |
Research Areas
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$ 365.00
$ 140.00
Cat# AP5860c
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