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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TANK Antibody (Center)   

TANK Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TANK Antibody (Center) AP5860c
    TANK Antibody (Center) (Cat. #AP5860c) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the TANK antibody detected the TANK protein (arrow).
  • IHC-P - TANK Antibody (Center) AP5860c
    TANK Antibody (Center) (Cat. #AP5860c) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TANK Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - TANK Antibody (Center) AP5860c
    TANK Antibody (Center) (Cat. #AP5860c) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q92844
Other Accession NP_004171.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47816 Da
Antigen Region 88-114 aa
Additional Information
Gene ID 10010
Other Names TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAF, TANK, ITRAF, TRAF2
Target/Specificity This TANK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-114 amino acids from the Central region of human TANK.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTANK Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TANK
Synonyms ITRAF, TRAF2
Function Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
Cellular Location Cytoplasm.
Tissue Location Ubiquitous.
Research Areas
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$ 295.00
$ 99.00
Cat# AP5860c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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