|Application ||WB, E|
|Other Accession||Q640K3, P55161, P28660, B0S6R1, NP_038464.1, NP_995314.1|
|Predicted||Zebrafish, Mouse, Rat, Xenopus|
|Calculated MW||128790 Da|
|Antigen Region||631-659 aa|
|Other Names||Nck-associated protein 1, NAP 1, Membrane-associated protein HEM-2, p125Nap1, NCKAP1, HEM2, KIAA0587, NAP1|
|Target/Specificity||This NCKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631-659 amino acids from the Central region of human NCKAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||NCKAP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HEM2, KIAA0587, NAP1|
|Function||Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.|
|Cellular Location||Cell membrane; Single-pass membrane protein; Cytoplasmic side Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side Note=At the interface between the lamellipodial actin meshwork and the membrane.|
|Tissue Location||Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle|
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