|Application ||WB, E|
|Calculated MW||62155 Da|
|Antigen Region||514-542 aa|
|Other Names||Solute carrier family 22 member 4, Ergothioneine transporter, ET transporter, Organic cation/carnitine transporter 1, SLC22A4, ETT, OCTN1, UT2H|
|Target/Specificity||This SLC22A4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 514-542 amino acids from the C-terminal region of human SLC22A4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC22A4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ETT, OCTN1, UT2H|
|Function||Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells.|
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