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> home > Products > Primary Antibodies > Antibody Collections > Immune system process > OTUD4 Antibody (N-term)
OTUD4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q01804 |
| Other Accession | NP_001096123.1, NP_059963.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 124045 Da |
| Antigen Region | 403-430 aa |
| Gene ID | 54726 |
|---|---|
| Other Names | OTU domain-containing protein 4, HIV-1-induced protein HIN-1, OTUD4, HIN1, KIAA1046 |
| Target/Specificity | This OTUD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 403-430 amino acids from the N-terminal region of human OTUD4. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OTUD4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OTUD4 (HGNC:24949) |
|---|---|
| Function | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase- substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). |
| Cellular Location | Cytoplasm. Nucleus. Note=Primarily cytoplasmic |
Research Areas
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$ 365.00
$ 140.00
Cat# AP5997a
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