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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   P-Glycoprotein (ABCB1) Antibody (Center)   

P-Glycoprotein (ABCB1) Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - P-Glycoprotein (ABCB1) Antibody (Center) AP6111a
    ABCB1 Antibody (L661) (Cat. #AP6111a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCB1 antibody detected the ABCB1 protein (arrow).
  • SPECIFICATION
  • CITATIONS: 2
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P08183
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 141479 Da
Antigen Region 647-677 aa
Additional Information
Gene ID 5243
Other Names Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243, ABCB1, MDR1, PGY1
Target/Specificity This P-Glycoprotein (ABCB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-677 amino acids from the Central region of human P-Glycoprotein (ABCB1).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsP-Glycoprotein (ABCB1) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCB1
Synonyms MDR1, PGY1
Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}
Tissue Location Expressed in liver, kidney, small intestine and brain
Research Areas
Citations ( 0 )

Background

The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

References

Saito, S., et al., J. Hum. Genet. 47(1):38-50 (2002). Kerb, R., et al., Pharmacogenomics 2(1):51-64 (2001). Cascorbi, I., et al., Clin. Pharmacol. Ther. 69(3):169-174 (2001). Hoffmeyer, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(7):3473-3478 (2000). Mickley, L.A., et al., Blood 91(5):1749-1756 (1998).

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$ 295.00
$ 99.00
Cat# AP6111a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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