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EDG4 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EDG4 Antibody (N-term) AP6140a
    Western blot analysis of lysate from MDA-MB-231 cell line, using EDG4 Antibody (N18)(Cat. #AP6140a). AP6140a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug.
  • WB - EDG4 Antibody (N-term) AP6140a
    The anti-EDG4 N-term Antibody (Cat.#AP6140a) is used in Western blot to detect EDG4 in HL60 lysate.
  • IHC-P - EDG4 Antibody (N-term) AP6140a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HBW0
Other Accession Q95KH4
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39084 Da
Antigen Region 3-32 aa
Additional Information
Gene ID 9170
Other Names Lysophosphatidic acid receptor 2, LPA receptor 2, LPA-2, Lysophosphatidic acid receptor Edg-4, LPAR2, EDG4, LPA2
Target/Specificity This EDG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human EDG4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEDG4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LPAR2
Synonyms EDG4, LPA2
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
Cellular Location Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles
Tissue Location Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon
Research Areas
Citations ( 0 )


EDG4 is a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.


Hu, Y.L., et al., J. Natl. Cancer Inst. 95(10):733-740 (2003).
Fujita, T., et al., Cancer Lett. 192(2):161-169 (2003).
Contos, J.J., et al., Genomics 64(2):155-169 (2000).
Zheng, Y., et al., FASEB J. 14(15):2387-2389 (2000).
Young, K.W., et al., J. Biol. Chem. 275(49):38532-38539 (2000).

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$ 295.00
$ 99.00
Cat# AP6140a
(40 western blots)
Availability: In Stock
Bulk Size
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