|Application ||WB, IF, E|
|Calculated MW||18641 Da|
|Antigen Region||134-166 aa|
|Other Names||Leptin, Obese protein, Obesity factor, LEP, OB, OBS|
|Target/Specificity||This Leptin (LEP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-166 amino acids from the C-terminal region of human Leptin (LEP).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Leptin (LEP) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Leptin (LEP) is an adipocyte-secreted protein that regulates body fat and endocrine functions. Leptin is similar to the mouse obesity protein encoded by the obese gene (ob). In mouse studies, mutations in this gene are linked to severe and morbid obesity.
Tank, J., et al., J. Clin. Endocrinol. Metab. 88(10):4955-4959 (2003).
Silha, J.V., et al., Eur. J. Endocrinol. 149(4):331-335 (2003).
Kazumi, T., et al., Metab. Clin. Exp. 52(9):1113-1116 (2003).
Mullington, J.M., et al., J. Neuroendocrinol. 15(9):851-854 (2003).
Catalano, S., et al., J. Biol. Chem. 278(31):28668-28676 (2003).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.