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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   MAGEC1 Antibody (C-term)   

MAGEC1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MAGEC1 Antibody (C-term) AP6175a
    Western blot analysis of MAGEC1 antibody (C-term) (Cat.# AP6175a) in K562 cell line lysates (35ug/lane). MAGEC1 (arrow) was detected using the purified Pab.
  • IHC-P - MAGEC1 Antibody (C-term) AP6175a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O60732
Other Accession NP_005453
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 849-880 aa
Additional Information
Other Names Melanoma-associated antigen C1, Cancer/testis antigen 71, CT71, MAGE-C1 antigen, MAGEC1
Target/Specificity This MAGEC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 849-880 amino acids from the C-terminal region of human MAGEC1.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAGEC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGEC1
Tissue Location Expressed in testis and in tumors of a wide variety of histologic types EMBL; AF064589; AAC18837.1; -; Genomic_DNA EMBL; AF056334; AAC24227.1; -; mRNA EMBL; AL022152; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC127771; AAI27772.1; -; mRNA CCDS; CCDS35417.1; -. [O60732-1] RefSeq; NP_005453.2; NM_005462.4. [O60732-1] RefSeq; XP_011529720.1; XM_011531418.2. [O60732-1] UniGene; Hs.132194; - ProteinModelPortal; O60732; - SMR; O60732; - BioGrid; 115272; 10 IntAct; O60732; 7 STRING; 9606.ENSP00000285879; - iPTMnet; O60732; - PhosphoSitePlus; O60732; - BioMuta; MAGEC1; - EPD; O60732; - MaxQB; O60732; - PaxDb; O60732; - PeptideAtlas; O60732; - PRIDE; O60732; - ProteomicsDB; 49577; - Ensembl; ENST00000285879; ENSP00000285879; ENSG00000155495. [O60732-1] Ensembl; ENST00000406005; ENSP00000385500; ENSG00000155495. [O60732-2] GeneID; 9947; - KEGG; hsa:9947; - UCSC; uc004fbt.4; human. [O60732-1] CTD; 9947; - DisGeNET; 9947; - EuPathDB; HostDB:ENSG00000155495.8; - GeneCards; MAGEC1; - H-InvDB; HIX0203313; - HGNC; HGNC:6812; MAGEC1 HPA; CAB015452; - HPA; HPA004622; - MIM; 300223; gene neXtProt; NX_O60732; - OpenTargets; ENSG00000155495; - PharmGKB; PA30558; - eggNOG; KOG4562; Eukaryota eggNOG; ENOG4111S70; LUCA GeneTree; ENSGT00760000118824; - HOGENOM; HOG000113459; - InParanoid; O60732; - OMA; SPHYFPQ; - OrthoDB; EOG091G0TJ0; - PhylomeDB; O60732; - TreeFam; TF328505; - GenomeRNAi; 9947; - PRO; PR:O60732; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000155495; - CleanEx; HS_MAGEC1; - Genevisible; O60732; HS InterPro; IPR037445; MAGE InterPro; IPR002190; MHD_dom PANTHER; PTHR11736; PTHR11736; 8 Pfam; PF01454; MAGE; 1 SMART; SM01373; MAGE; 1 PROSITE; PS50838; MAGE; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Tumor antigen CHAIN 1 1142 Melanoma-associated antigen C1 /FTId=PRO_0000156720 DOMAIN 908 1106 MAGE. {ECO:0000255|PROSITE- ProRule:PRU00127} MOD_RES 63 63 Phosphoserine MOD_RES 207 207 Phosphoserine MOD_RES 382 382 Phosphoserine MOD_RES 1063 1063 Phosphoserine VAR_SEQ 1 933 Missing (in isoform 2) /FTId=VSP_056382 VARIANT 25 25 C -> Y (in dbSNP:rs176036) /FTId=VAR_053501 VARIANT 151 151 T -> I (in dbSNP:rs176037) /FTId=VAR_053502 VARIANT 257 257 Q -> H (in dbSNP:rs176047) /FTId=VAR_053503 VARIANT 276 276 F -> S (in dbSNP:rs75148863) /FTId=VAR_053504 VARIANT 327 327 H -> Q (in dbSNP:rs176047) /FTId=VAR_060068 VARIANT 709 709 H -> Y (in dbSNP:rs56256227) /FTId=VAR_062121 CONFLICT 221 225 TQSTF -> SQRTS (in Ref. 1 and 2) CONFLICT 239 239 P -> S (in Ref. 1 and 2). CONFLICT 252 253 FS -> SP (in Ref. 1 and 2) CONFLICT 264 264 A -> P (in Ref. 1 and 2). CONFLICT 267 267 S -> P (in Ref. 1 and 2). CONFLICT 274 274 P -> R (in Ref. 1 and 2). CONFLICT 281 283 VSL -> LSI (in Ref. 1 and 2) CONFLICT 299 299 P -> A (in Ref. 1 and 2). CONFLICT 309 311 SSS -> PSF (in Ref. 2; AAC24227) CONFLICT 316 318 LSL -> VSI (in Ref. 2; AAC24227) CONFLICT 337 337 L -> P (in Ref. 2; AAC24227) CONFLICT 342 343 MT -> VS (in Ref. 2; AAC24227) CONFLICT 353 353 I -> L (in Ref. 2; AAC24227) CONFLICT 360 361 SA -> RT (in Ref. 2; AAC24227) CONFLICT 467 467 H -> Q (in Ref. 1; AAC18837) SEQUENCE 1142 AA; 123643 MW; 6C9AE820156F3C50 CRC64; MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP LQSPQSRSEG EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ SSPEGKDSLS PLEISQSPPE GEDVQSPLQN PASSFFSSAL LSIFQSSPES TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ SSPESTQSPF EGFPQSPLQI PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS SSSTLLSLFQ SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL LSIFQSSPES AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF EGFPQSPLQI PMTSSFSSTL LSILQSSPES AQSAFEGFPQ SPLQIPVSSS FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI PVSSSSSSST LLSLFQSSPE CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE DSLSPHYFPQ SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS PPEGPVQSPL HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE GEDSLSSLHF PQSPPEWEDS LSPLHFPQFP PQGEDFQSSL QSPVSICSSS TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS SFFSYTLASL LQSSHESPQS PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS SLSKSSPESP LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF RKAREFIEIL FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL ILILSIIFIK GTYASEEVIW DVLSGIGVRA GREHFAFGEP RELLTKVWVQ EHYLEYREVP NSSPPRYEFL WGPRAHSEVI KRKVVEFLAM LKNTVPITFP SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS SE
Research Areas
Citations (0)

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Background

MAGEC1 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, thus is about 800 residues longer than the other MAGE proteins. This gene is expressed in a significant proportion of tumors of various histological types, whereas it is silent in normal tissues, except testis. The function of this gene is unknown.

References

Jungbluth, A.A., et al., Int. J. Cancer 99(6):839-845 (2002).
Chen, Y.T., et al., Proc. Natl. Acad. Sci. U.S.A. 95(12):6919-6923 (1998).
Lucas, S., et al., Cancer Res. 58(4):743-752 (1998).
Lim, S.H., et al., Eur. J. Haematol. 67 (5-6), 332-334 (2001).

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Cat# AP6175a
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