|Application ||WB, IHC-P, E|
|Calculated MW||54151 Da|
|Antigen Region||394-423 aa|
|Other Names||Stromelysin-2, SL-2, Matrix metalloproteinase-10, MMP-10, Transin-2, MMP10, STMY2|
|Target/Specificity||This MMP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-423 amino acids from the C-terminal region of human MMP10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP10 degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).
Pendas, A.M., et al., Genomics 37(2):266-268 (1996).
Jung, J.Y., et al., Ann. Genet. 33(1):21-23 (1990).
Sirum, K.L., et al., Biochemistry 28(22):8691-8698 (1989).
Muller, D., et al., Biochem. J. 253(1):187-192 (1988).
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