|Application ||WB, IHC-P, FC, E|
|Calculated MW||57357 Da|
|Antigen Region||344-373 aa|
|Other Names||Matrix metalloproteinase-19, MMP-19, 3424-, Matrix metalloproteinase RASI, Matrix metalloproteinase-18, MMP-18, MMP19, MMP18, RASI|
|Target/Specificity||This MMP19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-373 amino acids from the C-terminal region of human MMP19.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941)|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The function of MMP19 has not been determined. This gene was previously referred to as MMP18 but has been renamed matrix metalloproteinase 19 (MMP19).
Sadowski, T., et al., Mol. Biol. Cell 14(11):4569-4580 (2003).
Impola, U., et al., Int. J. Cancer 103(6):709-716 (2003).
Mauch, S., et al., J. Immunol. 168(3):1244-1251 (2002).
Stracke, J.O., et al., J. Biol. Chem. 275(20):14809-14816 (2000).
Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).
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