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RAI3 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RAI3 Antibody (C-term) AP6239A
    Western blot analysis of hRai3-W343 (Cat. #AP6239a) in T47D cell line lysates (35ug/lane). RAI3 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NFJ5
Other Accession NP_003970
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40251 Da
Antigen Region 328-357 aa
Additional Information
Gene ID 9052
Other Names Retinoic acid-induced protein 3, G-protein coupled receptor family C group 5 member A, Orphan G-protein-coupling receptor PEIG-1, Retinoic acid-induced gene 1 protein, RAIG-1, GPRC5A, GPCR5A, RAI3, RAIG1
Target/Specificity This RAI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 328-357 amino acids from the C-terminal region of human RAI3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAI3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GPCR5A, RAI3, RAIG1
Function Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein Note=Localized in the plasma membrane and perinuclear vesicles
Tissue Location Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart
Research Areas
Citations (0)

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Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function for the protein from this retinoic acid-induced gene has not yet been determined; however, it may play a role in embryonic development and epithelial cell differentiation. Rai3 is a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. It may also be involved in interaction between retinoid acid and G protein signalling pathways.


Robbins, M.J., et al., Genomics 67(1):8-18 (2000).
Cheng, Y., et al., J. Biol. Chem. 273(52):35008-35015 (1998).
Cafferata, E.G., et al., Cell. Mol. Biol. (Noisy-le-grand) 42(5):797-804 (1996).

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Cat# AP6239A
(40 western blots)
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