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SOX30 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SOX30 Antibody (Center) AP6278c
    Western blot analysis of lysate from K562 cell line, using SOX30 Antibody (Center)(Cat. #AP6278c). AP6278c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O94993
Other Accession Q8CGW4, Q8WNV5
Reactivity Human
Predicted Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 373-403 aa
Additional Information
Other Names Transcription factor SOX-30, SOX30
Target/Specificity This SOX30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-403 amino acids from the Central region of human SOX30.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOX30 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX30
Function Transcriptional activator. Binds to the DNA sequence 5'- ACAAT-3' and shows a preference for guanine residues surrounding this core motif.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:10359848}
Tissue Location Expressed in testis. EMBL; AB022083; BAA37146.1; -; mRNA EMBL; AB022441; BAA37149.1; -; mRNA EMBL; BC033492; AAH33492.2; -; mRNA CCDS; CCDS4339.1; -. [O94993-1] CCDS; CCDS4340.1; -. [O94993-2] RefSeq; NP_001295094.1; NM_001308165.1 RefSeq; NP_008948.1; NM_007017.2. [O94993-2] RefSeq; NP_848511.1; NM_178424.1. [O94993-1] UniGene; Hs.529462; - UniGene; Hs.744348; - ProteinModelPortal; O94993; - SMR; O94993; - BioGrid; 116247; 18 IntAct; O94993; 16 MINT; O94993; - STRING; 9606.ENSP00000265007; - iPTMnet; O94993; - PhosphoSitePlus; O94993; - BioMuta; SOX30; - PaxDb; O94993; - PeptideAtlas; O94993; - PRIDE; O94993; - ProteomicsDB; 50621; - ProteomicsDB; 50622; -. [O94993-2] DNASU; 11063; - Ensembl; ENST00000265007; ENSP00000265007; ENSG00000039600. [O94993-1] Ensembl; ENST00000311371; ENSP00000309343; ENSG00000039600. [O94993-2] GeneID; 11063; - KEGG; hsa:11063; - UCSC; uc003lxb.1; human. [O94993-1] CTD; 11063; - DisGeNET; 11063; - EuPathDB; HostDB:ENSG00000039600.10; - GeneCards; SOX30; - H-InvDB; HIX0005360; - HGNC; HGNC:30635; SOX30 HPA; CAB009382; - HPA; HPA006159; - MIM; 606698; gene neXtProt; NX_O94993; - OpenTargets; ENSG00000039600; - PharmGKB; PA134876614; - eggNOG; ENOG410KD21; Eukaryota eggNOG; ENOG4112BUX; LUCA GeneTree; ENSGT00760000119274; - HOGENOM; HOG000070158; - HOVERGEN; HBG057980; - InParanoid; O94993; - KO; K09271; - OMA; STCPYSR; - OrthoDB; EOG091G0AGA; - PhylomeDB; O94993; - TreeFam; TF336594; - ChiTaRS; SOX30; human GenomeRNAi; 11063; - PRO; PR:O94993; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000039600; - CleanEx; HS_SOX30; - ExpressionAtlas; O94993; baseline and differential Genevisible; O94993; HS GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:UniProtKB GO; GO:0031960; P:response to corticosteroid; IEP:UniProtKB GO; GO:0007283; P:spermatogenesis; IEA:Ensembl GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW Gene3D; 1.10.30.10; -; 1 InterPro; IPR009071; HMG_box_dom InterPro; IPR036910; HMG_box_dom_sf Pfam; PF00505; HMG_box; 1 SMART; SM00398; HMG; 1 SUPFAM; SSF47095; SSF47095; 1 PROSITE; PS50118; HMG_BOX_2; 1 1: Evidence at protein level; Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation CHAIN 1 753 Transcription factor SOX-30 /FTId=PRO_0000048773 DNA_BIND 337 405 HMG box. {ECO:0000255|PROSITE- ProRule:PRU00267} COMPBIAS 6 41 Pro-rich COMPBIAS 564 646 Pro-rich VAR_SEQ 463 501 GETSPAIQLPTPAVQSPSPVTLFQPSVSSAAQVAVQDPS -> VHALTVGLPLAMEIFRVQCQNALVIMKTGTQNMRVSFQ L (in isoform 2) /FTId=VSP_002205 VAR_SEQ 502 753 Missing (in isoform 2) /FTId=VSP_002206 VARIANT 429 429 Q -> K (in dbSNP:rs12188040) /FTId=VAR_049563 VARIANT 749 749 V -> M (in dbSNP:rs889057) /FTId=VAR_024485 SEQUENCE 753 AA; 81854 MW; E9BF1409EE7FE81D CRC64; MERARPEPPP QPRPLRPAPP PLPVEGTSFW AAAMEPPPSS PTLSAAASAT LASSCGEAVA SGLQPAVRRL LQVKPEQVLL LPQPQAQNEE AAASSAQARL LQFRPDLRLL QPPTASDGAT SRPELHPVQP LALHVKAKKQ KLGPSLDQSV GPRGAVETGP RASRVVKLEG PGPALGYFRG DEKGKLEAEE VMRDSMQGGA GKSPAAIREG VIKTEEPERL LEDCRLGAEP ASNGLVHGSA EVILAPTSGA FGPHQQDLRI PLTLHTVPPG ARIQFQGAPP SELIRLTKVP LTPVPTKMQS LLEPSVKIET KDVPLTVLPS DAGIPDTPFS KDRNGHVKRP MNAFMVWARI HRPALAKANP AANNAEISVQ LGLEWNKLSE EQKKPYYDEA QKIKEKHREE FPGWVYQPRP GKRKRFPLSV SNVFSGTTQN IISTNPTTVY PYRSPTYSVV IPSLQNPITH PVGETSPAIQ LPTPAVQSPS PVTLFQPSVS SAAQVAVQDP SLPVYPALPP QRFTGPSQTD THQLHSEATH TVKQPTPVSL ESANRISSSA STAHARFATS TIQPPREYSS VSPCPRSAPI PQASPIPHPH VYQPPPLGHP ATLFGTPPRF SFHHPYFLPG PHYFPSSTCP YSRPPFGYGN FPSSMPECLS YYEDRYPKHE GIFSTLNRDY SFRDYSSECT HSENSRSCEN MNGTSYYNSH SHSGEENLNP VPQLDIGTLE NVFTAPTSTP SSIQQVNVTD SDEEEEEKVL RDL
Research Areas
Citations (0)

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Background

SOX30 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. SOX30 may act as a transcriptional regulator after forming a protein complex with other proteins, and it may be involved in the differentiation of developing male germ cells.

References

Koopman,P., Gene 328, 177-186 (2004)
Bullejos,M., Genetica 110 (2), 157-162 (2000)
Osaki,E., Nucleic Acids Res. 27 (12), 2503-2510 (1999)

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$ 295.00
$ 99.00
Cat# AP6278c
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Quantity:
(40 western blots)
Availability: In Stock
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