|Application ||WB, IHC-P, E|
|Other Accession||P62994, Q60631, Q07883, Q6GPJ9, P87379|
|Predicted||Xenopus, Chicken, Mouse, Rat|
|Calculated MW||25206 Da|
|Antigen Region||187-216 aa|
|Other Names||Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH|
|Target/Specificity||This GRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from human GRB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRB2 Antibody (Y209) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.|
|Cellular Location||Nucleus. Cytoplasm. Endosome. Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway.
Kondo,A., J. Biol. Chem. 283 (3), 1428-1436 (2008) Morimatsu,M., Proc. Natl. Acad. Sci. U.S.A. 104 (46), 18013-18018 (2007) Martinez,N., Cell. Signal. 19 (11), 2277-2285 (2007)
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