- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||40444 Da|
|Antigen Region||322-352 aa|
|Other Names||Vascular endothelial growth factor D, VEGF-D, c-Fos-induced growth factor, FIGF, FIGF, VEGFD|
|Target/Specificity||This VEGFD (VEGF4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-352 amino acids from the C-terminal region of human VEGFD (VEGF4).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VEGFD (VEGF4) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.|
|Tissue Location||Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.
Orlandini, M., et al., J. Biol. Chem. 278(45):44650-44656 (2003).
McColl, B.K., et al., J. Exp. Med. 198(6):863-868 (2003).
Rissanen, T.T., et al., Circ. Res. 92(10):1098-1106 (2003).
Nakamura, Y., et al., Clin. Cancer Res. 9(2):716-721 (2003).
Yokoyama, Y., et al., Br. J. Cancer 88(2):237-244 (2003).
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