|Application ||WB, E|
|Calculated MW||42563 Da|
|Antigen Region||50-81 aa|
|Other Names||Signal peptide peptidase-like 3, SPP-like 3, 3423-, Intramembrane protease 2, IMP-2, Presenilin homologous protein 1, PSH1, Presenilin-like protein 4, SPPL3, IMP2, PSL4|
|Target/Specificity||This SPPL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-81 amino acids from the N-terminal region of human SPPL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPPL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.|
|Cellular Location||Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Restricted to the early secretory compartment|
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Provided below are standard protocols that you may find useful for product applications.
Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. SPPL3 is one of several presenilin homologues/SPP-like proteins (PSHs/SPPL) that have been identified.
Grigorenko, A.P., et al., Biochemistry Mosc. 67(7):826-835 (2002).
Weihofen, A., et al., Science 296(5576):2215-2218 (2002).
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